Hundreds of compounds counteract specific behavioral effects of autism-linked gene variants in zebrafish, according to a new study that, its authors say, could guide precision gene-based medicine for some forms of autism. Many new drugs under investigation for the condition prove ineffective in clinical trials—in part because of its genetic and clinical heterogeneity. “A medication […]
Kettle of fish: More than two dozen strains of zebrafish with autism-linked gene variants share overlapping developmental pathways that lead to differences in social behavior, brain activity patterns and brain size, according to a new study. Molecular drivers of the differences include altered function in neuropeptide signaling, neuronal maturation and cell proliferation, which the authors […]
research roundup Zebrafish startle in response to a simulated predator approach and habitualize to repeated trials; fish missing the FMR1 gene — a model of fragile X syndrome — show muted behavioral habituation and neuronal changes in the visual and motor systems. Nature Communications Autistic women and other-gender adults have more service needs and experience […]
