The stringent statistical threshold used in genome-wide association studies (GWAS) hides low-frequency variants linked to autism and other conditions, a new preprint suggests. Lowering the threshold could reveal some of those variants, according to the study. “It’s really innovative,” says Carrie Bearden, professor of psychiatry and biobehavioral sciences at the University of California, Los Angeles, […]
A reanalysis of data published in a 2024 Nature paper spotlights the tension between curiosity and caution when searching for gene candidates. The 2024 study, led by Stephen Quake, professor of bioengineering and applied physics at Stanford University, claimed to reveal changes in gene expression associated with a mouse’s memory of a foot shock. Quake […]
