The largest study to date of leucovorin’s effectiveness for treating autism traits has been retracted because of data inconsistencies and statistical issues, according to a notice posted last week by the European Journal of Pediatrics. The study included 77 autistic children and is one of only five randomized clinical trials that have tested leucovorin, also […]
Microglia safeguard the proliferation and survival of young GABAergic interneurons by secreting insulin-like growth factor 1 (IGF-1), according to a new study of human brain tissue and organoids. The finding points to the potential origin of the brain signaling imbalance implicated in autism and other conditions. Microglia contribute to brain development, past findings show, but […]
This collection of Spectrum articles from the past 12 months highlights expert perspectives on autism’s heritability and its link to biological sex, the value of transdiagnostic frameworks, and the field’s future, among other topics.
