Early overgrowth: In their first few weeks of development, organoids with two intact copies of CHD8 (top) developed excitatory neurons more slowly than organoids missing a copy of the gene (bottom). Editor’s Note This article was originally published 11 January 2021, based on preliminary findings presented at the Society for Neuroscience annual meeting. The results […]
Subdued response: Organoids with microglia (bottom) show a lower interferon response (red) than organoids without microglia (top), suggesting that these immune cells help reduce cell stress. Adding non-neural brain cells called microglia to cortical organoids speeds up the rate of maturation of their neurons, increases the synchronization of their firing, and appears to reduce cellular […]
