Posts Tagged
‘mouse’

March 3, 2022

|

by: admin

|

Tags: chromosome, genes, model, mouse, reawaken, silenced, Spectrum

|

Categories: autism

Ready riser: Mouse cells that harbor a bioluminescent version of MECP2 also express a red fluorescent tag after pharmacological reactivation of the X chromosome (bottom), which is normally silenced. Courtesy of Mira-Bontembal and Tan, et al. A new mouse model may accelerate the discovery of gene-activating therapies to treat Rett syndrome, a condition related to […]

February 15, 2022

|

by: admin

|

Tags: brains, decreased, gut, linked, molecule, mouse, myelination, Spectrum

|

Categories: autism

That’s a wrap: Mice that produce high levels of the molecule 4EPS (top) have atypically sparse brain myelin — the fatty substance that sheathes axons and conducts neuronal signals — compared with controls (bottom). Mice chemically coaxed to produce high levels of an autism-linked gut molecule have anxiety-like behavior and unusual patterns of brain connectivity, […]

February 4, 2022

|

by: admin

|

Tags: Algorithm, Autism, gait, models, mouse, Spectrum, spots, subtle

|

Categories: autism

Motion picture: The software tracks points on a mouse’s body, from the nose to the tip of the tail, to automatically measure aspects of gait and posture. New software uses machine-learning to automatically detect and quantify gait and posture from videos of mice moving around their cage. The tool could accelerate research on how autism-linked […]

February 3, 2022

|

by: admin

|

Tags: Autism, Behavior, gene, immune, model, mouse, Social, Spectrum, tied

|

Categories: autism

Stacked effects: A gene mutation and immune stimulation together can render mice less social. Photography by Richard Drury Activating the immune system blunts social behaviors in mice missing a copy of the autism-linked gene SHANK3, according to a new study. But blocking TRPV4, a gene that encodes an ion channel involved in inflammatory responses, can […]

November 5, 2021

|

by: admin

|

Tags: Autism, breathing, form, issues, model, mouse, rare, reveals, root, Spectrum

|

Categories: autism

Exhale: In mice with a mutated copy of the TCF4 gene (right), nerve cells (pink) are in short supply compared to controls (left). Courtesy Daniel Mulkey The breathing difficulties in children with Pitt-Hopkins syndrome, a rare form of autism, stem from dysfunctional circuitry and a malignant sodium channel in the brain stem, according to a […]

November 4, 2021

|

by: admin

|

Tags: Autismlinked, bias, emerges, model, mouse, mutation, Sex, Spectrum

|

Categories: autism

Imbalanced Characteristics: Animals with mutated ADNP have motor difficulties that are more pronounced in female mice. Photography by Rick Dahms Mice with a mutation in an autism-related gene called ADNP show gender-specific changes in gene expression, behavior, and other traits, a new study shows. The mice can mimic some of the traits seen in humans […]

October 31, 2021

|

by: admin

|

Tags: Autism, birthday, Boy, Mickey, mouse, Silent, Surprise, Visit

|

Categories: autism

When it was little Nico’s birthday, his mother Vanessa Flores wanted to surprise him with something special. Nico has the autism spectrum and is non-verbal, so Flores has to be careful about what she surprises him with. He doesn’t like loud noises, so he needs something that doesn’t scare him. Photo: YouTube / ABC10 Then […]

October 16, 2021

|

by: admin

|

Tags: Autism, brain, improves, memory, models, mouse, Spectrum, stimulation

|

Categories: autism

Brain Boost: Electrical stimulation of the fornix weakened abnormal inhibitory signals in mice with CDKL5 mutations and restored their performance in learning and memory tasks. Manjurul / iStock Chronic electrical stimulation of the fornix, a bundle of nerve fibers deep in the brain, saves learning and memory deficits in mice with mutations in the autism-linked […]

October 12, 2021

|

by: admin

|

Tags: activity, beads, brain, images, light, Method, mouse, Spectrum

|

Categories: autism

Your browser does not support the video tag. Break A new imaging technique detects neurons that fire almost simultaneously across large parts of the brain tissue in living mice. The method could help researchers understand how extensive networks of neurons communicate and how these patterns differ between wild-type mice and mouse models of autism. According […]

September 10, 2021

|

by: admin

|

Tags: activity, Autism, brain, cluster, models, mouse, pattern, Spectrum

|

Categories: autism

Talk time: fMRI images of several autism mouse models show different communication patterns between brain regions. Courtesy of Alessandro Gozzi Brain scans from 16 mouse models of autism reveal at least four different patterns of brain activity, a new study suggests. The results again support the popular notion that autism is associated with a number […]

August 6, 2021

|

by: admin

|

Tags: Autism, boost, Drugs, models, mouse, multiple, serotonin, socialization, Spectrum

|

Categories: autism

Friend Zone: Mice with autism-related mutations overcome their disinterest in other mice after receiving MDMA or an experimental serotonin agonist. Stuart Wilson / Science Source Two unapproved drugs that increase the neurotransmitter serotonin significantly increase sociability in six autism mouse models, according to a new study. The findings build on decades of work suggesting that […]

July 20, 2021

|

by: admin

|

Tags: Autism, Behavior, Blocking, brain, key, model, mouse, pathway, reverses, Spectrum

|

Categories: autism

Extra spines: Mice with an extra copy of the MECP2 gene develop more spines on their motor cortex neurons (top) than wild-type mice during a learning task. An experimental drug normalizes this property (below). Neurons in mice with an autism-related mutation sprout outward protrusions, an overgrowth that is tracked with above-average motor learning. According to […]