Posts Tagged
‘model’

March 9, 2022

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by: admin

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Tags: Autism, behaviors, develop, Drug, mice, model, Motor, Social, Spectrum, Treatment, typical

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Categories: autism

Cell save: Deleting one copy of TSC1 in only Purkinje cells (red) reduces activity in those cells and alters social behavior in mice; a brief treatment with rapamycin seems to block these effects.Courtesy of Peter Tsai Briefly suppressing an overactive signaling pathway in juvenile mice that have an autism-linked mutation blocks them from developing some […]

March 3, 2022

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by: admin

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Tags: chromosome, genes, model, mouse, reawaken, silenced, Spectrum

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Categories: autism

Ready riser: Mouse cells that harbor a bioluminescent version of MECP2 also express a red fluorescent tag after pharmacological reactivation of the X chromosome (bottom), which is normally silenced. Courtesy of Mira-Bontembal and Tan, et al. A new mouse model may accelerate the discovery of gene-activating therapies to treat Rett syndrome, a condition related to […]

February 3, 2022

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by: admin

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Tags: Autism, Behavior, gene, immune, model, mouse, Social, Spectrum, tied

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Categories: autism

Stacked effects: A gene mutation and immune stimulation together can render mice less social. Photography by Richard Drury Activating the immune system blunts social behaviors in mice missing a copy of the autism-linked gene SHANK3, according to a new study. But blocking TRPV4, a gene that encodes an ion channel involved in inflammatory responses, can […]

Illustration by Laurène Boglio Hello and welcome to the community newsletter! I am your host, Chelsey B. Coombs, the engagement editor of Spectrum. We start this week with a paper on the strengths of autistic researchers by Aimee Grant, Senior Research Officer in Public Health at Swansea University, and Helen Kara, Honorary Senior Research Fellow […]

November 5, 2021

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by: admin

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Tags: Autism, breathing, form, issues, model, mouse, rare, reveals, root, Spectrum

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Categories: autism

Exhale: In mice with a mutated copy of the TCF4 gene (right), nerve cells (pink) are in short supply compared to controls (left). Courtesy Daniel Mulkey The breathing difficulties in children with Pitt-Hopkins syndrome, a rare form of autism, stem from dysfunctional circuitry and a malignant sodium channel in the brain stem, according to a […]

November 4, 2021

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by: admin

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Tags: Autismlinked, bias, emerges, model, mouse, mutation, Sex, Spectrum

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Categories: autism

Imbalanced Characteristics: Animals with mutated ADNP have motor difficulties that are more pronounced in female mice. Photography by Rick Dahms Mice with a mutation in an autism-related gene called ADNP show gender-specific changes in gene expression, behavior, and other traits, a new study shows. The mice can mimic some of the traits seen in humans […]

October 28, 2021

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by: admin

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Tags: accurately, Autism, Deeplearning, Diagnosis, model, predict, Spectrum

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Categories: autism

Continuous Prediction: A new model that uses medical records to screen for autism is working consistently across all U.S. states, suggesting it can help overcome structural barriers such as geographical differences in medical record keeping. Courtesy Ishanu Chattopadhyay A new model of deep learning appears to outperform a widely used screening test for identifying young […]

September 1, 2021

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by: admin

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Tags: Autism, inhibitor, migration, model, neuronal, normalizes, organoid, Protein, Spectrum

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Categories: autism

On the move: Neurons from month-old organoids with 16p11.2 deletions (right) migrate more slowly than those from control organoids (left). Inhibiting a protein that helps cells move or change shape prevents atypical neural migration in 3D clusters of brain cells that carry genetic variants associated with autism, according to a new study. The cell models […]

August 27, 2021

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by: admin

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Tags: Autism, Channel, contribution, genes, hint, mice, model, sodium, Spectrum

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Categories: autism

Channel markers: The cerebral cortex of mice with two mutated copies of SCN2A (bottom) has fewer sodium channels (green) than that of control mice (top). Some mutations in SCN2A, a gene reliably linked to autism, change the social behavior of mice by dampening the electrical activity of their neurons, according to a new study. SCN2A […]

July 20, 2021

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by: admin

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Tags: Autism, Behavior, Blocking, brain, key, model, mouse, pathway, reverses, Spectrum

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Categories: autism

Extra spines: Mice with an extra copy of the MECP2 gene develop more spines on their motor cortex neurons (top) than wild-type mice during a learning task. An experimental drug normalizes this property (below). Neurons in mice with an autism-related mutation sprout outward protrusions, an overgrowth that is tracked with above-average motor learning. According to […]

Illustration by Laurène Boglio Hello and welcome to this week’s community newsletter! I am your host, Chelsey B. Coombs, the engagement editor of Spectrum. If you would like to continue receiving this newsletter after today, please click here to receive an email from Mailchimp and update your settings. We start this week with a tweet […]

June 18, 2021

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by: admin

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Tags: Autism, captures, model, mouse, network, Neural, neurons, noisy, Spectrum

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Categories: autism

Mice lacking the autism-related SHANK3 gene use more neurons to engage in social behavior than control mice, reflecting a more disorganized, less efficient signaling network in the brain, according to a new study. Mutations in SHANK3 occur in 1 to 2 percent of autistic people and can also lead to a related disorder called Phelan-McDermid […]