On the move: Neurons from month-old organoids with 16p11.2 deletions (right) migrate more slowly than those from control organoids (left). Inhibiting a protein that helps cells move or change shape prevents atypical neural migration in 3D clusters of brain cells that carry genetic variants associated with autism, according to a new study. The cell models […]
Disorganized scaffolds: Immature brain cells from mutant CUL3 mice have a disordered cytoskeleton (right) compared to controls (left). Mutations in CUL3, a leading autism gene, can disrupt the movement of neurons during development and disrupt the precise assembly of the brain, suggests a new study. Correcting this misdirection could lead to therapy for autism in […]
