Cell save: Deleting one copy of TSC1 in only Purkinje cells (red) reduces activity in those cells and alters social behavior in mice; a brief treatment with rapamycin seems to block these effects.Courtesy of Peter Tsai Briefly suppressing an overactive signaling pathway in juvenile mice that have an autism-linked mutation blocks them from developing some […]
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‘Drug’
Spectrum’s Autism Drug Tracker provides interactive, curated information on hundreds of clinical studies on autism and related diseases. For details on how we filtered our data, please see the Drug Tracker Announcement article. See below for information on using the tracker. Which studies are included in the drug tracker? The Autism Drug Tracker includes clinical […]
Illustration by Verónica Grech Today we released the first iteration of our Autism Drug Trial Tracker, which provides interactive, curated information on more than 200 clinical studies on autism and related diseases. The data that powers the web application is freely available, as is the code that was used to scrape the data. We intend […]
If repeated: Deletions of ASH1L cause excessive grooming in mice, which treatment with the cancer drug vorinostat is alleviated. Mark Bowler / Science Source A cancer drug that boosts gene expression reduces repetitive behaviors and improves memory and sociability in a mouse model of autism, according to a new study. However, the treatment did not […]
Jeremy Veenstra-VanderWeele Professor of Psychiatry, Columbia University Jeremy Veenstra-VanderWeele uses molecular and translational neuroscience research tools to find new treatments for autism. View full bio Register for the September 28 webinar with Jeremy Veenstra-VanderWeele, Professor of Psychiatry at Columbia University, who will speak about the goals in developing new drugs for autism – and the […]
Illustration by Laurène Boglio Hello and welcome to this week’s community newsletter! I am your host, Chelsey B. Coombs, the engagement editor of Spectrum. Our first tweet comes from Dheeraj Roy, a postdoctoral fellow at the Massachusetts Institute of Technology in Cambridge, who highlighted his new study in Neuron on the role of the thalamus […]
“That puts us in a bad position,” agreed Dr. Karina Bishop, a geriatrician at the University of Nebraska Medical Center, added. From an ethical point of view, she added, “If this drug were available now, I would not be able to prescribe it.” As individual doctors grapple with advising patients, hospitals and health systems are […]