Impaired sensory studying in a mouse mannequin of fragile X syndrome; and extra
Tickle test: Sensory learning is altered in a mouse model of fragile X syndrome, according to a new preprint. The investigators recorded neuronal activity in response to repeated whisker stimulation in the mice and observed hampered long-term potentiation—synaptic changes that underlie learning—in pyramidal neurons. The researchers speculate that these findings may reflect “a significant deterioration of experience-dependent sensory perception” and may relate to other behavioral aspects of fragile X syndrome, such as cognitive inflexibility, sensory sensitivity and intellectual disability. bioRxiv
More autism research we spotted:
- “CA2 neurons show abnormal responses to social stimuli in a rat model of fragile X syndrome” bioRxiv
